Tianjin University has constructed a novel, targeted and highly-efficient nanosystem for combinational therapy of Alzheimer's Disease (AD). Such a multifunctional synergetic nanosystem could be a new candidate in achieving high-efficiency combination therapy for AD.

The research team was led by Professor Chang Jin. AD, commonly known as dementia, causes a continuous decline in thinking, behavioral and social skills that disrupts a person's ability to function independently. It remains the most prevalent neurodegenerative disease but as yet has no available effective treatment.

Schematic illustration of the novel nanosystem for combinational therapy for Alzheimer’s disease

According to the experimental results, AD mice treated with the novel nanodrugs have seen the AD dysfunction mitigated.

"This novel drug uses nanotechnology to co-encapsulate two AD therapeutic drugs in a nanoparticle for the first time, achieving a synergy and combination therapy," said team leader Professor Chang Jin.

"We hope to provide a new candidate for the therapy of AD with highly-efficient synergy and good biosafety, which could bring new hope to patients," Professor Chang added.

Relevant results from the team’s research have been published in "Advanced Science".